TCR Signal Labv2.4.1
Simulation running…28.4 s
T CELL
1TCR Binding
pMHC engages TCR; microclusters form.
2CD3 Phosphorylation
Lck phosphorylates ITAMs on CD3ζ.
3Calcium Flux
PLCγ1 activation induces Ca²⁺ influx and wave propagation.
4Gene Expression
NFAT, NF-κB, AP-1 activate transcription of target genes.
TCR–pMHC
engagement
engagement
CD3
Receptor
phosphorylation
phosphorylation
Ca²⁺ influx
store release
+ CRAC entry
store release
+ CRAC entry
Gene
transcription
transcription
1TCR Binding85%2CD3 Phosphorylation77%3Calcium Flux76%4Gene Expression77%
ANTIGEN-PRESENTING CELL
Educational simulation · Values are illustrative and are not clinical or experimental predictions.